Fig. 2: Spontaneous seizures and increased seizure susceptibility in Gabrg2+/A105T mice. | Cell Death Discovery

Fig. 2: Spontaneous seizures and increased seizure susceptibility in Gabrg2+/A105T mice.

From: A knock-in mouse model for GABRG2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment

Fig. 2

A Representative image of a Gabrg2+/A105T mouse exhibiting a rigid posture and extended legs during a spontaneous convulsive seizure. B Seizure scores in Gabrg2+/A105T mice compared to WT littermates following intraperitoneal injection of PTZ (40 mg/kg) (n = 10 per group). C Seizure duration in Gabrg2+/A105T and WT mice induced with PTZ injection (n = 8 for WT and n = 7 for A105T). D Latency to hind limb extension and percentage of mice reaching hind limb extension after PTZ injection. E Representative EEG recording from Gabrg2+/A105T and WT mice with or without PTZ injection. F Maximal EEG amplitude in Gabrg2+/A105T and WT mice (n = 4 per group). Data are presented as mean ± SD and * P < 0.05, ** P < 0.01 using Kruskal–Wallis test (2B), Unpaired t-test (2C) or two-way ANOVA followed by Sidak’s multiple comparisons test (2F).

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