Fig. 4: Altered γ2 subunit expression and hippocampal pathology in Gabrg2+/A105T mice. | Cell Death Discovery

Fig. 4: Altered γ2 subunit expression and hippocampal pathology in Gabrg2+/A105T mice.

From: A knock-in mouse model for GABRG2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment

Fig. 4

A Representative Western blot images of γ2 subunit expression in the whole brain of Gabrg2+/A105T and WT mice. B Quantification of total γ2 subunit expression in the whole brain of Gabrg2+/A105T mice compared to WT controls (n = 3 per group). C Representative Western blot images of γ2 subunit expression in specific brain regions (cerebellum, cortex, hippocampus, and thalamus) of Gabrg2+/A105T and WT mice. D Quantification of total γ2 subunit expression in specific brain regions (cerebellum, cortex, hippocampus, and thalamus) (n = 4 per group). E Representative Western blot images of membrane γ2 subunit expression in specific brain regions (cerebellum, cortex, hippocampus, and thalamus) of Gabrg2+/A105T and WT mice. F Quantification of membrane γ2 subunit expression in specific brain regions (cerebellum, cortex, hippocampus, and thalamus) (n = 3 per group). G Example mIPSCs recorded from WT (left, red) and Gabrg2+/A105T (right, blue) hippocampal neurons. H Average amplitudes of mIPSCs (n = 6 per group). I Average frequency of mIPSCs (n = 6 per group). Data are presented as mean ± SD and * P < 0.05, ** P < 0.01 vs. WT using two-way ANOVA followed by Sidak’s multiple comparisons test (D, F) or Unpaired t-test (B, H, I).

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