Fig. 1: Inhibition of CSF1R by PLX5622 rapidly depletes all microglia in the retina.
From: Dual extra-retinal origins of microglia in the model of retinal microglia repopulation
a Scheme of PLX5622 administration and time points for observation. b Spatial distributions of retinal microglia show that the cell numbers are reduced after PLX5622 administration. Each green dot represents a microglial cell. c Representative confocal images show microglial numbers are reduced in the OPL of the retina after PLX5622 administration. d Quantification of microglial density in the OPL of normal retinas and the retinas upon PLX5622 treatment. Green: GFP. S: superior; I: inferior; N: nasal; T: temporal; PLX5622: PLX5622 formulated diet. The data are presented as mean ± SD; NS not significant; *p < 0.05 to D0; **p < 0.01 to D0; ***p < 0.001 to D0. One-way ANOVA with Bonferroni’s post hoc
