Fig. 2: Extensive upregulation of abnormal gametogenesis is found in tumors from p53−/− mice.
From: Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance
a Sections of paired normal tissues derived from p53−/− and p53+/+ mice were stained with Oct4 antibody. The relative ratio of obvious Oct4+ cells appeared in the p53−/− mice with different ages was shown. b Sections of paired thymic lymphoma of p53−/− mouse and normal thymus of p53+/+ mouse were stained with H&E or antibodies against the indicated proteins. c Sections of malignant teratoma, spleen, and sarcoma from p53−/− mice were stained with Oct4 antibody. d The pie chart showed the spontaneous tumor types with different percentage in p53−/− mice. The age of tumor formation was counted at the appearance of obvious tumors. The plot showed the age of appearing obvious tumors in the different spontaneous tumor types in p53−/− mice. e The correlation between the appearance of PGC-like cells and tumor formation in a variety of tissues from p53−/− mice. f Section from spontaneous tumors of p53−/− mice were stained with antibody against Prdm14, Nanos3, Vasa, or H&E. Section of sarcoma stained with Vasa antibody showed an oocyte-like tumor cell (arrow). g Sections were stained with H&E (scale bar = 20 μm)
