Fig. 3: PGC-like cells from p53−/− mice show strong tumorigenicity potential.
From: Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance
a In all, 100 Stellar− or Stellar+ cells sorted from two different p53−/− lymphomas by FACS were injected subcutaneously into nude mice, and tumor volume was measured at 6 weeks after injection. The plots showed relative tumor volume from paired sorted Stellar− and Stellar+ cells within 6 weeks (n = 3). **p < 0.01. b 100 Stellar+ cells after cultured in dish for 30 days. The cultures from the Stellar+ cells after cultured for 30 days were injected subcutaneously into nude mice and tumorigenicity was analyzed. The plot showed the distinct tumorigenicity of sorting Stellar+ cells and cultured Stellar+ cells. c Bright-field and Oct4-GFP fluorescence image of primary cultured thymic lymphomas at different time points. The plot showed the distinct tumorigenicity of total thymic lymphoma cells and primary cultures from thymic lymphoma after cultured for 21 days (scale bar = 40 μm in b and 20 μm in c)
