Fig. 4: AbTCR-T cells release less CRS-related cytokines than CAR-T cells, including monocyte-lineage-derived IL-6. | Cell Discovery

Fig. 4: AbTCR-T cells release less CRS-related cytokines than CAR-T cells, including monocyte-lineage-derived IL-6.

From: A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release

Fig. 4

a ET190L1-AbTCR-T cells (AbTCR) release less cytokines than ET190L1-CAR-T cells (CAR) during in vitro killing assays. T cells were incubated with target cells for 16 h at an E:T ratio of 5:1. Secreted cytokine levels in the supernatant were measured. Data shown are representative of three independent experiments. b Cytokine expression after trans-well co-culture. T cells, targets (CD19+ NALM-6 cells) were placed in plate wells, and monocyte-lineage cells (APCs) were place in transwell inserts. Supernatants were collected after 18 h of co-cultures

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