Fig. 4: Modeling of VAV2 mutations by MDSA analysis.
From: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas
a Merged representative conformations of wild type and mutant VAV2 generated by 20 ns Molecular Dynamics Simulation Analysis (MDSA). b Residue-specific root mean square fluctuations (RMSF) in simulations. V872I mutation in VAV2 leads to instability of the whole protein, especially the N-terminal and the C-terminal SH2/3 domains, as shown in the black boxes
