Fig. 2: The mAbs specifically neutralized and recognized Asian-lineage ZIKV strain. | Cell Discovery

Fig. 2: The mAbs specifically neutralized and recognized Asian-lineage ZIKV strain.

From: A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein

Fig. 2

a, b Neutralization activity of the mAbs against Asian-lineage (a) and African-lineage (b) strains of ZIKV. 100 PFU of Asian ZIKV strain SZ-WIV01 (a) or African ZIKV strain MR766 (b) was mixed with two-fold serial dilutions of purified anti-ZIKV mAbs 3E8, 5F8, 5G3, 8A2, 9C3 or control mAb D5. Then neutralizing activity of these mAbs was determined by the plaque reduction neutralization test (PRNT). Results represent the mean ± SEM of three independent experiments. c Flow cytometry analysis of reactivities of the mAbs with Asian and African strains of ZIKV. ZIKV/SZ-WIV01- and ZIKV/MR766-infected Vero cells were incubated with anti-ZIKV mAbs, negative control mAb D5 or positive control mAb 4G2, and then analyzed by flow cytometry.

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