Fig. 4: Location and sequence of the P31 epitope. | Cell Discovery

Fig. 4: Location and sequence of the P31 epitope.

From: A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein

Fig. 4

a Ribbon diagram of top view of the E protein dimer. The fusion loop (green) from one monomer (cornflower blue) and the glycan loop (red; residues 151 to 165) from another monomer (gray) are shown. b Amino acid sequence alignment of E proteins from different flaviviruses displaying sequence variation in the corresponding region of P31. Black arrows above the alignment represent secondary structure elements (β-strands) of ZIKV. The epitope region (P31) of anti-ZIKV mAbs is boxed. The red triangle denotes N-linked glycosylation sites. The positions where the sequences of tested viruses possessed residues identical to those of ZIKV/H/PF/2013 strain are indicated with dots.

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