Fig. 4: Conformational dynamics of ORC1-AAA+ domain in human ORC1–5. | Cell Discovery

Fig. 4: Conformational dynamics of ORC1-AAA+ domain in human ORC1–5.

From: Structural insight into the assembly and conformational activation of human origin recognition complex

Fig. 4

a, b Crystal structure of the autoinhibited DmORC (PDB: 4XGC) (a) and a hypothetic atomic model of the active HsORC (PDB: 5UJM) (b) shown in cartoon and surface representations in AAA+ view. Orc2-WHDs are highlighted by red dash circles. c–f Cryo-EM maps of four subgroups, groups I (c), group II (d), group III (e), group IV (f), classified based on the conformations of ORC1-AAA+. ORC1-AAA+ domains are colored blue (d), green (e), and red (f), respectively. ORC2-WHDs are colored dark gray. Densities of other domains are shown in transparent surface representation and superimposed with the atomic model of HsORC1–5. The positions of ORC4-RecAs and ORC1-Lids are marked by blue and black dash circles, respectively.

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