Fig. 3: The structure of AFF4-THD dimer. | Cell Discovery

Fig. 3: The structure of AFF4-THD dimer.

From: Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription

Fig. 3

a Overview of AFF4-THD dimer. From left to right, bottom view, side view, and top view. One molecule is shown in cyan while the other is shown in slate. The blue and red dots denote the N- and C-terminal of AFF4-THD. b The antiparalleled beta-strand is shown. Upper: cartoon. Lower: sticks. The hydrogen bonds are shown in magenta dash line and the length of hydrogen bond is labeled. c The helix bundle formed by α5, α6, α5’, and α6’ is shown as cartoon. Left: top view. Right: side view. d The hydrophobic groove formed by α5, α5’, and α6’ is shown as surface, while α6 is shown as cartoon with key residues shown as sticks. The orientation of view is same to that in c. Left: top view. Right: side view.

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