Fig. 3: Protein-DNA interactions observed in the AsfvAP/DNA-1 complex.
From: A unique DNA-binding mode of African swine fever virus AP endonuclease
a Cartoon view showing the conformations and relative orientations of the R1, R2 and R3 regions, which are colored in green. b Detailed interactions between DNA-1 and the R1 region. DNA-1 and R1 are shown as cartoon. The interacting residues (His8 and Ser14) and nucleotides (A13 and C2) are highlighted by sticks. dRP nucleotide of DNA-1 and Cys16-Cys20 disulfide bond of R1 are also highlighted by sticks. c–d Detailed interactions between DNA-1 and the R2 region. Zn2+ ions and water molecule are shown as spheres in black and red, respectively. e Detailed interactions between DNA-1 and the R3 region. Besides Asn273 of the R3 region, the conserved Tyr81 residue is also highlighted by sticks. f Interactions between nick region nucleotides and AsfvAP residues.
