Fig. 1: Overview of the REF6 domains.
From: Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms
a Domain architecture of the REF6 protein based on the solved structure. Domain boundaries are indicated by residue numbers. JmjN, JmjC, acidic region, ZnF1-2 domain, hinge, ZnF3 domain, ZnF4 domain, and basic region are shown. b Sequence alignment of REF6 proteins from different species. Secondary structural elements of the DNA-free and DNA-bound REF6 structure are calculated using DSSP and colored in green and cyan, respectively. Cylinders, waved lines and arrows represent α-helices, 310 helices, and β-strands, respectively. The residues coordinating the four Zn2+ ions are shown as blue, magenta, red, and yellow, respectively. The invariant residues between different species are shown in pink. The sequences used are: REF6 from Arabidopsis thaliana (NP_680116.2), lysine-specific demethylase JMJ705 from Oryza sativa Japonica Group (XP_015621377.1), GLYMA_04G192000 from Glycine max (KRH63699.1), REF6 from Zea mays (AQK40026.1), REF6 from Brassica napus (XP_013724852.1), REF6 from Nicotiana attenuata (XP_019243504.1), REF6 from Gossypium hirsutum (XP_016718821.1), REF6 from Medicago truncatula (XP_013460954.1).
