Fig. 6: Essential roles of FSK and exendin-4 in in vitro pancreatic islet expansion.
From: In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals
a-d qRT-PCR analysis of the expression of islet cell identity markers (a), proliferation and cell cycle markers (b), pluripotency and regeneration markers (c) and islet and pancreatic progenitor markers (d) in pregnant mouse-expanded clusters after 3 days of culture with PIEM or PIEM without FSK or exendin-4. *P < 0.05; **P < 0.01; ***P < 0.001; cell clusters cultured in PIEM without FSK or exendin-4 were compared with those cultured in complete PIEM. The data are shown as the mean ± SEM of at least three independent experiments. Data were analysed using unpaired two-tailed Student’s t-test.
