Table 2 Protein sequence alignments of the representative conopeptides.

From: The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus

Name

Conotoxin sequence

GenBank accession no.

(a) Analgesic activity

MVIIA

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P05484.2

CONOT097

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--- (Present study)

Bt168

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KU563979.1

Bt175

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KU564050.1

(b) Antiaddictive activity

AuIB

P56640.2

Bt007

KU564009.1

Bt004

KU564008.1

Bt008

KU317629.1

(c) Insecticidal activity

ImI

KJ801971.1

Bt001

KU563886.1

Bt006

KU563888.1

Bt027

KU564013.1

  1. The list is simplified from Supplementary Table S18 for a 3D-structural comparison in Fig. 5.
  2. Note: Conserved residues (with similar properties) among different conopeptides are highlighted in the same background color. *, Amidated C-terminus.
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