Fig. 2: Single-cell immune profiling of T cells. | Cell Discovery

Fig. 2: Single-cell immune profiling of T cells.

From: Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease

Fig. 2

a Blood TCR diversity comparison between PD patients and healthy controls. TCR diversity was measured by D50, which is proven robust for the sequencing library size. P value was estimated using two-sided Wilcoxon test. b The association between the number of T cell clonotypes and the number of cells per clonotype. Downsampling was used to avoid bias caused by the total number of detected T cells between PD patients and healthy controls. The dashed line separates nonclonal and clonal cells, with the latter identified by repeated usage of αβTCRs. P value was estimated using paired samples Wilcoxon test. c UMAP plot showing the distribution of clonally expanded T cells. Each dot represents a unique clonotype in a T cell cluster, and the coordinates are the average coordinates of the cells belonging to this clonotype. The color and size of the dot both reflect the clone size in each cluster. d Clonal composition of T cells in samples. The top panel shows the distribution of clonotypes by size (NA, = 1, ≥2, ≥20 and ≥100 cells, NA represents cells with no αβTCR sequence detected). The bottom pie charts show the cell type composition of clonotypes from each sample stratified by clone size.

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