Fig. 5: GSEA and biological process analysis for CD3E+CD8A+CD4− clusters of top 20 TCR clonotypes paired scRNA-seq data from Patient group vs. HD group. | Cell Discovery

Fig. 5: GSEA and biological process analysis for CD3E+CD8A+CD4− clusters of top 20 TCR clonotypes paired scRNA-seq data from Patient group vs. HD group.

From: Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals

Fig. 5

a Distribution of each group in CD8A+KLRB1+CXCR4+ terminal differentiation T subset (left panel) and CD8A+CD160hi effector T subset (right panel). b Using GSEA to analyze expressed genes from CD3E+CD8A+CD4− clusters of top 20 TCR paired scRNA-seq data, 2 gene sets of interferon response significantly upregulated in Discharged group comparing with HD group (n = 6 per group). NES, normalized ES; FDR, false discovery rate; NOM p, normalized p value. Top 20 BP enrichment analysis of DEGs from CD3E+CD8A+CD4− clusters of top 20 TCR paired scRNA-seq data, which were upregulated in Discharged group vs. HD group analysis (n = 6 per group) (c) and Follow-up vs. HD groups (n = 7 in Follow-up group, n = 6 in HD group) (d). DC, Discharged group; FU, Follow-up group; HD, Healthy Donor group.

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