Fig. 1: SIRT2 protein level negatively correlates with the severity of ALD in patients.
From: SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury
a Representative IHC images of liver tissues from ALD patients for the lower (SIRT2low, IRS ≤ 5, n = 47) and higher (SIRT2high, IRS > 5, n = 55) expressions of SIRT2. The scale bar represents 50 μm. b–f Plots of serum ALT (b) and AST (c), cl.Caspase-3 IRS scores (d), and the percentages of liver tissues with high and low necrosis (e) or fibrosis (f) in SIRT2low and SIRT2high groups. Statistical significance was determined by two-tailed Student’s t-test (b–d), Pearson’s χ2 test (e, f). Data are shown as means ± SD and were considered statistically significant at *P < 0.05, **P < 0.01, and ***P < 0.001.
