Fig. 1: Overall structure of human ATP13A2.
From: Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2
a, b 3.0-Å-resolution cryo-EM map (a) and ribbon model (b) of human ATP13A2 in E1P-ADP state. The A, N, and P domains and the transmembrane domain are colored orange, rose, brown, and magenta, respectively. The N-terminus domain and C-terminus extension domain of ATP13A2 are blue and purple. The same color scheme is used throughout this manuscript. The ADP and Pi are shown as spheres. c Topology diagram of human ATP13A2. Conserved domains and TM helices are schematically illustrated. Note that the helix of TM4 is unraveled halfway by a P5B-ATPase conserved PP(A/V)LP motif. d Cryo-EM maps of human ATP13A2 in E1 state and E2-Pi state.
