Fig. 2: CTD of ATP13A2 interacts with P-domain, affects protein expression and stability.
From: Cryo-EM structures and transport mechanism of human P5B type ATPase ATP13A2
a Overall structure of E1P-ADP state ATP13A2 in surface representation. The CTD is shown as a purple stick model. b Ribbon representation of the domain interface between CTD and P-domain. Polar interactions are shown as red dashed lines. c Sequence alignment of the CTD of human ATP13A2 to ATP13A5 using ESPript3. Residues are considered as highly similar are colored in red and framed in blue. d Immunoblotting of HEK293F overexpressing five ATP13A2 CTD deletion truncations (5, 10, 15, 20, and 25 amino acids were deleted from C-terminus, respectively).
