Fig. 2: Structural differences between hPol I and yPol I.
From: Structure of the human RNA polymerase I elongation complex
a Structural comparison of hPol I (marine) and yPol I (gray) (PDB: 5M3F)16 in the ECpost state. b–f Close-up views of structural differences around the clamp between hPol I and yPol I and the differences are indicated with arrows. The hPol I subunits are labeled. Two dashed circles in c, d indicate the residues 1133–1168 of A135 and residues 52–68 of Rpb6 in yPol I, respectively. These two regions do not exist in hPol I. Two different views of the structural difference in the clamp are shown in the top panels of e and f and more details are shown at the bottom panels. Two dashed circles in g, h indicate residues 721–732 and 1078–1131 insertions of RPA1 that exist in hPol I but not in yPol I, respectively.
