Fig. 5: SIRT6 restricts HBV gene expression through deacetylating H3K9ac and H3K56ac on HBV mini-chromosome. | Cell Discovery

Fig. 5: SIRT6 restricts HBV gene expression through deacetylating H3K9ac and H3K56ac on HBV mini-chromosome.

From: Multiomics interrogation into HBV (Hepatitis B virus)-host interaction reveals novel coding potential in human genome, and identifies canonical and non-canonical proteins as host restriction factors against HBV

Fig. 5

a SIRT6 co-immunoprecipitated with HBcAg in 293FT cells. b SIRT6 and HBcAg co-localized in the nuclei of Huh7.5.1 cells during HBV replication. Scale bars, 20 μm. c–f ChIP assays were performed using indicated antibodies with cells upon either HBV transfection alone (c), or in combination with SIRT6 overexpression (d) or knockdown (e) or MDL800 treatment (f). *P < 0.05, **P < 0.01, ***P < 0.001. ChIP data were acquired in Huh7.5.1 cells and were presented as bar chart (n = 3 per group).

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