Fig. 1: Results of genome-wide association study of survival in ovarian cancer patients. | Cell Discovery

Fig. 1: Results of genome-wide association study of survival in ovarian cancer patients.

From: Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women

Fig. 1

a Manhattan plot of results of genome-wide association analysis for survival in the discovery stage. Each point represents the negative log P value for an association with overall survival. The horizontal blue line shows the suggestive threshold of 1 × 10−5. b Regional plot for association statistics at the 3p26.1 region. Results are shown for SNPs in the region 500 kb up- or downstream of the leading SNP rs7631664. Each dot represents the negative log P value for the association statistics. The top associated SNP is colored in purple (circle in the discovery stage and diamonds in the combined stages) and the remaining SNPs are colored according to linkage disequilibrium values (r2) with the top SNP in the discovery stage. c Kaplan–Meier estimates of the overall survival time for ovarian cancer patients stratified by genotypes of rs7631664. The left, middle, and right represent the discovery cohort from SOCS, replication cohort from TOCS, and combined cohort, respectively. All P < 0.001 for the log-rank test.

Back to article page