Fig. 4: Maps of the identified Kmea and Kcr on HeLa histones. | Cell Discovery

Fig. 4: Maps of the identified Kmea and Kcr on HeLa histones.

From: Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Fig. 4

Schematic of the sequences of the 5 core histone proteins and 1 variant histone sequence (H2AZ) with sites of Kmea and Kcr identified in HeLa cells. The key for the modifications is as follows: Kmea, blue squares; Kcr, orange diamonds. Kmea sites include both those detected by IP-HPLC/MS/MS with pan Kmea antibody as well as sites that were validated by co-elution or ozonolysis in HeLa cells. Kcr sites were detected in our previous publication using HeLa cell histones11.

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