Fig. 1: Host genetic signals associated with the tongue dorsum microbiome.
From: Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome
a Manhattan plot shows the genetic variants associated with the tongue dorsum microbial taxa. The horizontal gray and black lines represent the genome-wide (p = 5 × 10−8) and study-wide (p = 3.16 × 10−11 for 1583 independent mgGWAS tests) significance levels, respectively. Three loci that were associated with the tongue dorsum microbiome and reached study-wide significance were marked in red. Their located genes and associated microbial taxa with p values of < 3.16 × 10−11 were also listed. b Network representation of the 455 gene-microbiome associations identified in the tongue dorsum mgGWAS at the genome-wide significance. Each node represents either a gene (blue diamonds) or a microbial taxon (circles with different colors according to phylum). Each edge is an association between one gene and one microbial taxon. The bold edge represented study-wide significant associations as shown in a. The genes that linked to at least two different microbial taxa from different phyla were also listed.
