Fig. 3: Interaction of human SLC2A9 locus (rs3775944), serum uric acid, and three tongue dorsum bacteria.
From: Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome
a–c The three panels present the associations of SLC2A9 variation with microbial abundances of the three most significantly associated taxa: Oribacterium uSGB 1215, Oribacterium uSGB 489, and L. umeaense), which reached study-wide significance in the discovery (n = 2017) cohort and were well replicated in the replication (n = 1333) cohort. d–f Correlations between three tongue dorsum bacteria and serum uric acid. Spearman’s correlation coefficient (rho) and p value were shown. g Schematic representation of the interaction among SLC2A9 locus (rs3775944), serum uric acid, and three tongue dorsum bacteria: SLC2A9 as a uric acid transporter, its minor allele T of SNP rs3775944 associated with lower serum uric acid, and genetic predisposition to lower serum uric acid level is associated with lower abundance of Oribacterium uSGB 1215, Oribacterium uSGB 489, and Lachnoanaerobaculum umeaense.
