Fig. 2: Differential proportional analysis reveals significantly expanded or contracted cell lineages associated with the progression of TAAD. | Cell Discovery

Fig. 2: Differential proportional analysis reveals significantly expanded or contracted cell lineages associated with the progression of TAAD.

From: Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection

Fig. 2

a Visualization of cellular density reveals dramatic changes in proportion for smooth muscle cells and macrophages in BAPN vs CTRL. b The proportion of cells from each sample in each cluster. c The relative proportion of each lineage at each stage. Square root transformation was performed on the y-axis. d The relative proportion of each cluster at each time point. In a and b, cells are randomly sampled for equal numbers in each sample (n = 7316). In c and d, a DPA test was performed. *P < 0.05, **P < 0.01; CTRL, control; EDO, endothelial cell; FB, fibroblast; MAC, macrophage; PCD, pericardial cell; SMC, smooth muscle cell.

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