Fig. 5: The heterogeneity of macrophages during the development of TAAD. | Cell Discovery

Fig. 5: The heterogeneity of macrophages during the development of TAAD.

From: Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection

Fig. 5

a Heatmap showing distinct expression profiles of the three macrophage subpopulations. b The expression of markers for pro-inflammatory chemokines, M1-polarized, M2-polarized, and tissue-resident macrophages in the three subpopulations. c GO terms enriched in the molecular signatures of each subpopulation. Adjusted P value of hypergeometric test <0.05. d Subpopulation-specific regulons of each subpopulation revealed by SCENIC analysis. e smFISH results showing the spatial distribution of the three macrophage subpopulations in mouse aorta. Scale bars, 50 μm. TA, tunica adventitia; TM, tunica media.

Back to article page