Fig. 6: The pro-inflammatory macrophage subpopulation is a predominant source of most detrimental molecules in the development of TAAD. | Cell Discovery

Fig. 6: The pro-inflammatory macrophage subpopulation is a predominant source of most detrimental molecules in the development of TAAD.

From: Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection

Fig. 6

a Split violin plot showing the expression of genes encoding MMP family proteins in the mouse aorta of the BAPN and CTRL groups. scRNA-seq data from all three time points were considered. Log2 transformation was performed on the y-axis. CTRL control. b Experimental procedure for bulk RNA-seq of the aorta tissues from TAAD patients (n = 8) and healthy donors (n = 6). c Principal component analysis showing the separation of the TAAD from the healthy group. d The expression of the markers of the three macrophage subpopulations and three MMP genes in aorta tissues from TAAD patients and healthy donors. The statistical threshold of the differential expression test was set to be a q value < 0.05. e Experimental procedure for bulk RNA-seq of CD11b+ aortic cells, CD11b− aortic cells, and CD11b+ PBMCs from TAAD patients (n = 4). f The expression of the markers of the three macrophage subpopulations in CD11b+ aortic tissues and corresponding CD11b+ PBMCs. g The expression of the markers of the three macrophage subpopulations and three MMP genes in CD11b+ and CD11b− aortic cells from TAAD patients and healthy donors. The statistical threshold of the differential expression test was set to be a q value < 0.05.

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