Fig. 4: Genome-wide DNA demethylation in cancer cells is strongly enriched in heterochromatin regions. | Cell Discovery

Fig. 4: Genome-wide DNA demethylation in cancer cells is strongly enriched in heterochromatin regions.

From: Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma

Fig. 4

a Global DNA methylation levels (1 kb tile) of single cells in each subclone of P11. b Genome-wide DNA demethylation heatmap (10 Mb window) of cancer cells compared to all Norm_epi cells in P11. c Spearman correlations between DNA demethylation levels and the densities of genomic landmarks under different resolutions in each patient.

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