Fig. 5: NDRs and TF motif enrichment in PDAC. | Cell Discovery

Fig. 5: NDRs and TF motif enrichment in PDAC.

From: Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma

Fig. 5

a Spearman correlations between chromatin accessibility across gene bodies (including 15 kb flanking regions) and corresponding RNA expression levels in each cell type. b Venn diagram indicating the NDR numbers in cancer cells and Norm_epi cells. NDRs in two types of cells are defined as a shared NDR when they have at least a 100-bp overlap. Merged NDRs in two types of cells were defined with two standards: (1) NDRs were merged when they had at least a 100-bp overlap; (2) each merged NDR was detected in at least 11 cells in Norm_epi cell group and 53 cells in the cancer cell group. c Representative cancer-specific and Norm_epi-specific motifs and corresponding candidate TFs. d RNA expression levels, chromatin accessibility, and DNA methylation levels in the promoter regions of each candidate TF. The statistical test was carried out using the Wilcoxon rank-sum test. n.s., no significance; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. e, f Overall survival of PDAC patients grouped by two representative genes. The survival data were obtained from the TCGA database.

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