Fig. 2: Full chemical synthesis and thermal stability analysis of self-adjuvanting peptides. | Cell Discovery

Fig. 2: Full chemical synthesis and thermal stability analysis of self-adjuvanting peptides.

From: CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Fig. 2

a Synthesis of SZU-101 derivatives and SZU-101-peptide conjugations. Reaction conditions: a, EDCI/NHS, DMSO, 15 °C, overnight; b, 3, EDCI/NHS, DMSO, 15 °C, overnight; c, LY54, NaHCO3, DMF/H2O, room temperature (RT), 2 h; d, P67, NaHCO3, DMF/H2O, RT, 1 h. b–d HPLC profile of stability analysis of LY54–101 for 5 days, 10 days and, 30 days at 4 °C (b), 25 °C (c), and 40 °C (d). The horizontal axis represents the retention time (min), and the vertical axis represents the absorbance (mAU).

Back to article page