Fig. 5: CoVac501 induced Th1-baised responses and T-cell immune memory in cynomolgus macaques. | Cell Discovery

Fig. 5: CoVac501 induced Th1-baised responses and T-cell immune memory in cynomolgus macaques.

From: CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Fig. 5

a, b PBMCs were collected from the monkeys 70 days after the first dose of vaccine and IFN-γ+, TNF-α+, IL-2+, IL-4+, IL-6+, and IL-10+ intracellular cytokine staining assays by flow cytometry for CD8+ T (a) and CD4+ T (b) cells in response to RBD after 8 h antigen stimulation. c PBMCs were collected from monkeys 42 days after the first dose of vaccine and naive T cells (CD28+, CCR7+ and CD45RA+), effector T cells (CD28 –, CCR7–, and CD45RA+) and memory T cells (CD28+, CCR7–, and CD45RA–) were tested by flow cytometry. d RNA sequencing results were analyzed for immune cell levels and immune processes through the xCell or Molecular Signatures Database. All data are presented as the means ± SEM.

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