Fig. 3: mutI-tri-RBD induced significantly higher titer of neutralizing antibody responses against the Delta and Beta variants compared with homo-tri-RBD.
From: Design of a mutation-integrated trimeric RBD with broad protection against SARS-CoV-2
a, b The pseudo-virus (a) and live-virus (b) neutralizing antibody titers against the SARS-CoV-2 Delta variant induced by mutI-tri-RBD in the sera collected on day 7 post-immunization (D28 in Fig. 2a) were distinctly higher than those elicited by homo-tri-RBD. c, d The pseudo-virus (c) and live-virus (d) neutralizing antibody titers against SARS-CoV-2 Beta variant induced by mutI-tri-RBD were also obviously higher than those elicited by homo-tri-RBD. Data are presented as means ± SEM. P values were calculated by using one-way ANOVA followed by Sidak’s multiple comparison test. *P < 0.05, ****P < 0.001, ns, not significant.
