Fig. 2: Characterization of DNA 6mA in GSCs and glioblastoma cell lines by heavy stable isotope tracer [15N5]-dA. | Cell Discovery

Fig. 2: Characterization of DNA 6mA in GSCs and glioblastoma cell lines by heavy stable isotope tracer [15N5]-dA.

From: Rare and misincorporated DNA N6-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells

Fig. 2

a Flow diagram of tracing methylase-deposited DNA 6mA in glioma cells by [15N5]-dA. b UHPLC-MS/MS chromatograms of the labeled dA and 6mA in the genome of glioma stem cells (GSCs). c, d Quantification of the labeled dA (c) and 6mA (d) in the genomic DNA of human GSCs and human glioblastoma cell lines. ND, not detectable.

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