Fig. 4: Increase of DNA 6mA and 5 mC in IDH1-mutant gliomas (glioblastoma excluded).

a DNA 6mA content in IDH1^wt and IDH1^mut glioma tissues. IDH1^wt, n = 14; IDH1^mut, n = 20. b, c DNA 5mC (b) or 5hmC (c) content in IDH1^wt and IDH1^mut glioma tissues. IDH1^wt, n = 15; IDH1^mut, n = 21. c Kaplan–Meier curve of Low-Grade glioma patients’ survival. Patients were stratified into the “IDH1^mut” group (n = 393) and the “IDH1^wt” group (n = 117). e Kaplan–Meier curve of Low-Grade glioma and glioblastoma patients’ survival. Patients were stratified into the “IDH1^mut” group (n = 781) and the “IDH1^wt” group (n = 1346). a–c The glioblastomas were excluded. Statistical significance was determined by Student’s unpaired t-test. d, e Data were obtained from The Cancer Genome Atlas clinical dataset. Significance was determined by log-rank analysis.