Fig. 5: The level of misincorporated DNA 6mA is correlated with overall survival rates in human glioblastomas. | Cell Discovery

Fig. 5: The level of misincorporated DNA 6mA is correlated with overall survival rates in human glioblastomas.

From: Rare and misincorporated DNA N6-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells

Fig. 5

a Pearson correlations between 6mA level and overall survival time of GBM patients (n = 35). b Kaplan–Meier curve of GBM patients survival according to 6mA levels in GBM tissues. Patients were stratified into the “high level 6mA” group (n = 18) and the “low level 6mA” group (n = 17). c, d Kaplan–Meier curve of GBM patients survival according to 5mC (c) or 5hmC (d) levels in GBM tissues. Patients were stratified into the “high level 5mC/5hmC” group (n = 18) and the “low level 5mC/5hmC” group (n = 17). e Multivariate Cox proportional hazards ratios for survival based on 6mA level adjusted for 5mC and 5hmC of patients. f Multivariate Cox proportional hazards ratios for survival based on 6mA level adjusted for TERT promoter mutation and MGMT promoter methylation of patients. a Statistical significance was determined by Student’s unpaired t-test. b–d Significance was determined by log-rank analysis.

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