Fig. 8: m6A treatment selectively preserves a subset of the cells and stimulates their stemness and proliferation. | Cell Discovery

Fig. 8: m6A treatment selectively preserves a subset of the cells and stimulates their stemness and proliferation.

From: Rare and misincorporated DNA N6-methyladenine is a hallmark of cytotoxic stresses for selectively stimulating the stemness and proliferation of glioblastoma cells

Fig. 8

a–c Progressive inhibition of U87 cell proliferation by m6A treatment, as shown by phase light images (a), Ki67 staining (b), and CCK8 assay (c). Scale bar: 50 μm. d, e Selective preservation of a subset of GBM cells with potential stem cell-like properties. Formation of neurosphere-like structures with m6A treatment (d); Strong Ki67 (e, upper panel) and Sox2 staining (e, middle panel) with the neurosphere-like objects; Enhanced Tuj1 staining at the peripherals of the neurosphere-like objects (e, lower panel). Scale bar: 50 μm.

Back to article page