Fig. 1: Proteomic analysis of Omicron-induced host responses.
From: Proteomic characterization of Omicron SARS-CoV-2 host response
a Distances of host responses of circulating proteomes in a principal component analysis (PCA) plot. The position of centroid colored in gray is the average value of the PC1 and PC2 coordinates of each sample in a patient group. The line connecting the centroid and each sample represents their distance. b 62 differentially expressed proteins between the Omicron and non-COVID-19 groups with fold change > 1.2 and Benjamini–Hochberg (B-H) adjusted P < 0.05, as shown in a heatmap. These proteins are enriched in three selected pathways by Ingenuity Pathway Analysis (IPA) (P < 0.05). c–e Differential expression of GPT/ALT1 and GOT1/AST (c), CRP, SAA1 and SAA2 (d), CSK and GRB2 (e) across the five patient groups. PrV, pre-vaccination; PoV, post-vaccination; OM, Omicron; NO, non-Omicron; RE, non-COVID-19 respiratory virus infection. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; *****P < 0.00001.
