Fig. 5: SFRP4+ stromal cells promote the regeneration of endometrial epithelial glands and full thickness endometrial injury through IGF1 signaling pathway in vivo.
From: SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration
a H&E staining of rat uterus 1 week after operation in endometrial injury group (injury), material only group (Gelma), SFRP4+ stromal cell therapy group (Gelma + stroma) and cell compound IGF1 inhibitor group (Gelma + stroma + s1091). b comparison of endometrial thickness in different operation groups, n = 5, *p < 0.05; ***p < 0.001. c Immunohistochemical staining of FOXA2 showed endometrial glands 1 weeks after after operation in injury group, Gelma group, Gelma + stroma group and Gelma + stroma + s1091 group. d quantification of endometrial glands in in different operation groups, n = 5. scale bar, 500 μm.
