Fig. 5: Biological insights of thyroid tumor subtypes based on proteotypic data.
From: Artificial intelligence defines protein-based classification of thyroid nodules
a Rose chart plotting the DEP counts of corresponding pairwise comparison for follicular-pattern tumors and control samples (cPTC). The threshold that we used was fold change > 4 and adjusted P-value < 0.01. The pink and blue colors represent counts of upregulated and downregulated proteins in the Rose chart, respectively. b Box plots showing CRABP1 and NAMPT dysregulated in six histological tumor subtypes, especially between FTC and FA. P-values were calculated by one-way ANOVA for six-group comparison in the box plots. c UMAP plot for 186 proteins distinguishing Hürthle cell tumors from other follicular neoplasms. d Network map showing expression of key mitochondrial proteins implicated in Hürthle cell neoplasms. e UMAP plot for 401 proteins distinguishing FTC from cPTC, with fvPTC as an intermediate phenotype. f, g Heatmap showing DEPs (f) in FTC compared with fvPTC and cPTC, with pathways (g) indicated in the chord plot.
