Fig. 3: Expression heterogeneity and stem-like malignant cells in SBC. | Cell Discovery

Fig. 3: Expression heterogeneity and stem-like malignant cells in SBC.

From: Single-cell transcriptome reveals cellular hierarchies and guides p-EMT-targeted trial in skull base chordoma

Fig. 3

a 60,626 malignant cells were clustered into six clusters using unbiased clustering. b The UMAP plot of the expression of SBC subpopulation and cancer stem-cell markers. c Stem score was calculated in each malignant cluster. Cluster 3 showed the highest stem score. ****P-value ≤ 0.0001. d The heatmap showed the markers and pathway enrichment results of each SBC malignant cluster. Genes with high expression levels were labeled on the right side of the heatmap. e, f The RNA velocity trajectory and the latent time of SBC malignant cells.

Back to article page