Fig. 7: Cell ligand-receptor inference analysis of immune cells in VAT. | Cell Discovery

Fig. 7: Cell ligand-receptor inference analysis of immune cells in VAT.

From: Single-cell sequencing unveils key contributions of immune cell populations in cancer-associated adipose wasting

Fig. 7

a Interaction heatmap plotting the number of the ligand-receptor pairs between each immune cell type in VAT. Crosstalk of immune cells in VAT from patients without CAC is shown in the upper area, while that from patients with CAC is shown in the lower area. b Connectome web analysis of interacting immune cells based on the expression of paired ligands and receptors. The size of nodes denotes the number of pairs involved in each cell type, and the color saturation of the line is proportional to the amount of the pairs between two nodes. c Dot plots showing the expression of ligands (left) and receptors (right) implicated in the interaction pairs of CD8+ T cells in each immune cell type. Color saturation reflects the log2 fold-change of the indicated gene expressed in cells from patients with cachexia compared with patients without cachexia.

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