Fig. 5: ESC- or iPSC-derived iNK cells eradicate human tumor cells in xenograft animals. | Cell Discovery

Fig. 5: ESC- or iPSC-derived iNK cells eradicate human tumor cells in xenograft animals.

From: Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

Fig. 5

a Procedure design for NK cell treatment in tumor-bearing animals. b BLI images of the xenograft models (Tumor only, Tumor + UCB-NK, Tumor + iPSC-iNK and Tumor + ESC-iNK, n = 5 each group). The radiance indicates tumor burden. c Statistics of the total flux (p/s) of the xenograft models (Tumor only, Tumor + UCB-NK, Tumor + iPSC-iNK and Tumor + ESC-iNK, n = 5 each group). d Kaplan-Meier survival curves of the xenograft models (Tumor only, Tumor + UCB-NK, Tumor + iPSC-iNK and Tumor + ESC-iNK, n = 5 each group) (P < 0.001, Log-rank test). Median survival times were shown. e The body weights of treated mice on Day 35 after iNK cell injection. Data were analyzed by one-way ANOVA (c) or two-tailed independent t-test (e). NS, not significant. ESC: human ESC line hPSC-2; iPSC: human iPSC line hPSC-6.

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