Fig. 5: The brains of Cmpk2-KO and -KI mice have extensive calcification deposits.
From: Loss of function of CMPK2 causes mitochondria deficiency and brain calcification
a Brain sections of 14-month-old WT and Cmpk2-KO mice were stained with H&E, Von Kossa, alizarin red, PAS, and Alcian blue. b Coronal and sagittal micro-CT scan of the brain of a Cmpk2-KO mouse at 13 months. Arrowheads indicate the high-density foci (these are calcification deposits). Ctx cortex, Crb cerebellum, Thal thalamus. c Progressive development of calcification deposits in the brains of Cmpk2-KO mice at 10, 12, and 14 months. Calcifications are indicated by alizarin red and Von Kossa staining. d A gene diagram for the Cmpk2-KI mouse model of the c.2 T > C mutation of the Cmpk2 gene. e Brain sections of 12-month-old Cmpk2-KI mice were stained with H&E, Von Kossa, alizarin red, PAS, and Alcian blue. The calcification volume is indicated at the left bottom of a series of continuous brain sections. Scale bar, 100 μm in a, c, and e.
