Fig. 6: Acinar-to-ductal transdifferentiation occurs during caerulein-induced pancreatitis.
From: Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas
a Schematic diagram illustrating the experimental strategy for Tam treatment, caerulein-induced AP and CP. b H&E staining of pancreatic sections from the indicated mice. c–f Immunostaining of tdT, zsGreen and CK19 (c, e) or Amylase (d, f) on pancreatic sections collected from the indicated mice. White arrowheads, zsGreen+ ductal cells. Yellow arrowheads, tdT+ ductal cells. g Diagram illustrating that a subset of ductal cells is derived from tdT+ acinar cells during the caerulein-induced pancreatitis. Scale bars, 100 μm. Each image is representative of 5 individual samples.
