Fig. 4: π-stacking interdomain interaction network at the threefold interface. | Cell Discovery

Fig. 4: π-stacking interdomain interaction network at the threefold interface.

From: Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney

Fig. 4

a View of the βH–βB′ interface within the interdomain trimer for E2p (left) and E2o (right). βH (orange; cyan) forms three hydrogen bonds with βB′ (green; magenta) in both E2p and E2o. The E2o interface has an additional slipped-parallel π-stacking interaction between Phe383 and Phe253′. Inset shows offset rings from view along the parallel axes. b π-stacking interactions present at the threefold axis of E2o trimer but absent in E2p trimer. Expanded views along the threefold axis of E2o show an extended π-electron network formed by F253, F383, and Y419.

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