Fig. 3: Paternally activated MRD is essential for ZGA in human.
From: Human zygotic genome activation is initiated from paternal genome
a Violin plots showing the expression levels of PG specifically expressed genes at the 8-cell stage in the indicated human embryos. Wilcoxon rank sum test was used. b Bar plot showing the numbers of maternal genes whose transcripts are degraded in haploid or bi-parental embryos from 4-cell to 8-cell or morula stages. c Plot showing the expression levels of LSM1 in human haploid and bi-parental embryos. d Bar plot showing the read numbers for LSM1 transcripts from paternal and maternal genomes in human bi-parental 8-cell embryos (samples 3c and 5c). The RNA-seq data are from35. The locations of SNPs, and the alleles at these SNP loci in maternal and paternal genomes are indicated. e Scatter plot showing the expression levels of maternally degraded genes between LSM1 KD and control 8-cell embryos. The genes upregulated in LSM1 KD embryos are labeled in red, while the genes downregulated in LSM1 KD embryos are labeled in blue. The numbers of maternally degraded genes belonging to DEGs are indicated. f Scatter plot showing the expression levels of ZGA genes between LSM1 KD and control 8-cell embryos. The genes upregulated in LSM1 KD embryos are labeled in red, while the genes downregulated in LSM1 KD embryos are labeled in blue. The numbers of ZGA genes belonging to DEGs are indicated.
