Fig. 4: Epigenetic states at ZNF675 and LSM1 loci.
From: Human zygotic genome activation is initiated from paternal genome
a Plot showing the global DNA methylation levels of parental genomes in human PG and AG embryos at the 8-cell stage. b Bar plots showing the number of total DHSs and parentally specific DHSs in human PG and AG embryos at the 8-cell stage. c Transcription factor binding motif enrichment in the parentally specific DHSs at the 8-cell stage. The sizes of circles represent the p values of enrichment. The colors in the circles represent the expression levels of transcription factors in the corresponding PG or AG embryos. d Scatter plot showing the RNA expression of the ZGA genes whose promoters harbor AG-specific DHSs. e Genome browser view of RNA expression and epigenetic states at ZNF675 locus. The blue shadow indicates a putative enhancer region associated with ZNF675. f Genome browser view of RNA expression and epigenetic states at LSM1 locus. The blue shadow indicates the promoter region of LSM1.
