Fig. 3: S/M/N/E- or RBD-specific T-cell responses against WT SARS-CoV-2 ex vivo. | Cell Discovery

Fig. 3: S/M/N/E- or RBD-specific T-cell responses against WT SARS-CoV-2 ex vivo.

From: SARS-CoV-2 vaccination-infection pattern imprints and diversifies T cell differentiation and neutralizing response against Omicron subvariants

Fig. 3

a, d Representative flow cytometry plots in the I-I-δ, I-I-ο, M-M-ο, and I-I-I groups showing S/M/N/E- or RBD-specific CD4+ T-cell responses (IFN-γ+) (a) and CD8+ T-cell responses (IFN-γ+) (d) against WT peptide pools of S/M/N/E and RBD. b, e Frequency and number of all S/M/N/E- or RBD-specific CD4+ T cells (b) and CD8+ T cells (e) in the I-I-δ (n = 25), I-I-ο (n = 21), M-M-ο (n = 9), and I-I-I (n = 40) groups. The number in magenta indicates the mean in the frequency and number of detected responses. c, f S/M/N/E- or RBD-specific CD4+ T cells (c) and CD8+ T cells (f) expressing IFN-γ and TNF are shown. Comparisons were performed using Mann–Whitney tests. Data in bar charts are shown as the means ± SEM and those in dot plots as the means ± interquartile range. Each dot represents one donor. *P < 0.05, **P < 0.01.

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